Different biological models are used at PKDERM :

• Skin models (2D culture of keratinocytes, fibroblasts, melanocytes, etc.), 3D skin equivalent models, and human skin explants)

• Liver models (hepatocytes in 2D and 3D culture)

• 2D and 3D respiratory models (Calu-3, EpiAirway, PCLS…)

With more than 20 years of experience in pharmaceutical industry, PKDERM offers a wide range of innovative in vitro tests :

• Example of in vitro toxicology tests: dermal absorption, skin and eye irritation, sensitization, cytotoxicity, phototoxicity, endocrine properties, PK & metabolism, drug transporters and DDI.